Abstract: A high-throughput cross-layer optimization strategy based on the interference management for the multi-hop multi-base-station wireless network environment was proposed. In the physical layer the successive interference cancellation was used to realize the interference management. In the up layers, first the Voronoi algorithm was used to achieve the zoning, second based on the min-hop algorithm, the initial link allocation and multi-hop routing scheme was established, third optimize the scheme based on the multi-time-slot allocating or multi-hop routing, and at last try to find a better strategy in each iteration. Theoretical analysis shows that the strategy has a polynomial time complexity, and the simulation results show that the entire network throughput has a 2 to 5 fold increase by using interference management.