智能科学与技术学报 ›› 2022, Vol. 4 ›› Issue (4): 610-616.doi: 10.11959/j.issn.2096-6652.202207

• 学术论文 • 上一篇    

结合Attention U-Net与瓶颈检测的肺部细胞图像分割方法

邵虹1, 左常升2, 张萍1   

  1. 1 沈阳工业大学信息科学与工程学院，辽宁 沈阳 110870
    2 沈阳工业大学软件学院，辽宁 沈阳 110870
  • 修回日期:2021-07-15 出版日期:2022-12-15 发布日期:2022-12-01
  • 作者简介:邵虹（1974− ），女，博士，沈阳工业大学信息科学与工程学院教授，主要研究方向为图像处理与模式识别、智能信息处理
    左常升（1996− ），男，沈阳工业大学软件学院硕士生，主要研究方向为智能信息处理
    张萍（1996− ），女，沈阳工业大学信息科学与工程学院硕士生，主要研究方向为智能信息处理

Lung cell image segmentation method combining Attention U-Net and bottleneck detection

Hong SHAO1, Changsheng ZUO2, Ping ZHANG1   

  1. 1 School of Information Science and Engineering, Shenyang University of Technology, Shenyang 110870, China
    2 School of Software, Shenyang University of Technology, Shenyang 110870, China
  • Revised:2021-07-15 Online:2022-12-15 Published:2022-12-01

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摘要：

肺部病理图像具有边界模糊、细胞重叠交织等特点，为了解决细胞分割问题，提出结合Attention U-Net与瓶颈检测的肺部细胞图像分割方法。首先对采集到的图像进行双边滤波和拉普拉斯锐化处理，在去除噪声的同时突出细胞边缘细节，加大目标物与背景的对比；然后对Attention U-Net进行训练，利用训练的模型对病理图像进行分割，得到细胞区域；在模型分割结果的基础上，以面积、周长、圆度为筛选条件建立判别模型，区分单个细胞和重叠细胞；对细胞重叠区域采用瓶颈检测方法确定分离点，采用椭圆拟合方法进行边界修正，得到最终分割结果。实验结果表明，该方法能够对复杂的肺部细胞病理图像进行分割（包括单个细胞与重叠细胞），取得了较好的分割结果。

关键词: 肺部病理图像, 细胞分割, AttentionU-Net, 瓶颈检测, 椭圆拟合

Abstract:

Lung pathological images are characterized by fuzzy boundary and overlapping and interweining cells.In order to solve the problem of cell segmentation, a lung cell image segmentation method combining Attention U-Net and bottleneck detection was proposed.Firstly, bilateral filtering and Laplacian sharpening were performed on the collected images to highlight the details of cell edges and increase the contrast between the target and the background while removing the noise.Then the Attention U-Net was trained, and the pathological images were segmented using the trained model to obtain the cell regions.Based on the segmentation results of the model, the discriminant model was established with area, circumference and roundness as screening conditions to distinguish single cell from overlapping cells.The bottleneck detection method was used to determine the separation point in the overlapping region of cells, and the ellipse fitting method was used to modify the boundary, and the final segmentation result was obtained.Experimental results show that this method can segment complex lung cell pathological images (including single cell and overlapping cells) and achieve good segmentation results.

Key words: lung pathology image, cell segmentation, Attention U-Net, bottleneck detection, ellipse fitting

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