Abstract: According to the defects of the existing 3G base station location optimization algorithms and the characteristics of the TD-SCDMA network, an optimization program was proposed for TD-SCDMA network base station location based on immune algorithm. A mathematical model of base station location was established. A population initialization program based on opposition-based learning and an elite crossover strategy were also designed, and the immune optimization algorithm framework was presented. The experiments’ result shows that the algorithm cannot only get higher network coverage with a relatively smaller consideration, but also have better convergence.