Abstract: For the Android platform security problem, a mobile client and server collaborative malware detection proposal was proposed, where mobile client application was mainly based on permission detection technology and implemented lightweight testing. The server-side detection system is mainly responsible for testing suspicious samples submitted by the mobile terminals, meanwhile implements the functions of software behavior analysis, signature library updates, and mobile client synchronization, etc. The server-side detection techniques include permission-based detection technology, bytecode-based static detection technology and root-based dynamic detection technology. The result of the experiment shows that the three detection techniques can achieve better detection results.