全场光学相干层析三维成像技术研究

doi:10.11959/j.issn.1000-436x.2017293

通信学报 ›› 2017, Vol. 38 ›› Issue (12): 121-127.doi: 10.11959/j.issn.1000-436x.2017293

全场光学相干层析三维成像技术研究

牟宁¹,高万荣¹,魏喆强²

¹ 南京理工大学电子工程与光电技术学院，江苏南京 210094
² 无锡市第三人民医院病理科，江苏无锡 214041

修回日期:2017-11-28 出版日期:2017-12-01 发布日期:2018-01-19
作者简介:牟宁（1981-），女，江苏南京人，南京理工大学博士生，主要研究方向为全场相干光学层析、医学成像系统、生物医学图像处理等。|高万荣（1961-），男，陕西铜川人，博士，南京理工大学教授、博士生导师，主要研究方向为生物医学和生物光学。|魏喆强（1973-），男，江苏无锡人，无锡市第三人民医院主任医师，主要研究方向为临床病理诊断。
基金资助:
国家自然科学基金资助项目(61275198);国家自然科学基金资助项目(60978069)

Research on full-field optical coherence tomography

Ning MU¹,Wan-rong GAO¹,Zhe-qiang WEI²

¹ School of Electronic Engineering and Optoelectronic Technology，Nanjing University of Science and Technology，Nanjing 210094，China
² Pathology Department，Wuxi No.3 People’s Hospital，Wuxi 214041，China

Revised:2017-11-28 Online:2017-12-01 Published:2018-01-19
Supported by:
The National Natural Science Foundation of China(61275198);The National Natural Science Foundation of China(60978069)

摘要/Abstract

摘要：

首先在对全场光学相干层析（FFOCT）系统的数学建模和理论分析基础上，给出FFOCT系统的轴向和平面分辨率；然后采用全场光学相干层析三维成像技术对人体食管、子宫等器官的正常和癌变样本进行内部三维成像提取，获取了微米级高分辨率的层析图像，可以清晰显示组织的细胞间质和肌纤维结构；研究实验中把FFOCT成像的结果与传统病理切片显微图像进行了比较，FFOCT系统不仅能观察到传统病理切片可以看到的细胞块形态，而且不需要切割、染色等烦琐耗时的处理，就能观察到传统方法难以获取的深度结构。该技术可以应用于癌症的早期诊断和手术中的快速诊断。

关键词: 全场光子相干层析, 医学成像, 成像性能, 高分辨率

Abstract:

Full-field optical coherence tomography(FFOCT)was used for imaging the interior part of an object.Firstly，the mathematical modeling and performance analysis of the FFOCT system mounted was provided.Secondly，images of several different human tissues were obtained by FFOCT system，including esophagus，uterus，etc.The images of different depths of the same tissue were shown and compared.It was the first time in China that FFOCT was used for generating depth images on human esophagus and uterus;high-resolution images had been obtained for different depths without cutting the tissue sample，in which intercellular substance and myofibril structure could be clearly identified.As the in-depth structure could be imaged without the process needed for frozen and paraffin sectioning methods，the technology could been highly valuable for early cancer diagnosis and pathological analysis in tumor research.

Key words: FFOCT, medical image, imaging performance, high resolution

中图分类号:

TN247

牟宁,高万荣,魏喆强. 全场光学相干层析三维成像技术研究[J]. 通信学报, 2017, 38(12): 121-127.

Ning MU,Wan-rong GAO,Zhe-qiang WEI. Research on full-field optical coherence tomography[J]. Journal on Communications, 2017, 38(12): 121-127.

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全场光学相干层析三维成像技术研究

Research on full-field optical coherence tomography

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