小型化无透镜微流控片上生物成像检测

doi:10.11959/j.issn.2096-3750.2019.00111

Abstract

Abstract:

The conventional high-resolution optical microscopy for biomedical imaging has high cost and low portability due to bulky optical lenses system.To realize miniaturized imaging,the recent advance of lensless microfluidic on-chip imaging technique based on the integration of CMOS image sensor and microfluidics has provided one promising solution.Therefore,the architecture,principle,problems and improvement solutions for different miniaturized lensless microfluidic on-chip bio-imaging,including shadow imaging,holographic imaging,fluorescent imaging and color imaging were reviewed.And the deficiencies and possible development directions were discussed.

Key words: on-chip imaging, lensless, microfluidic, CMOS image sensor, miniaturization

CLC Number:

TP391

Jin CHEN,Xiwei HUANG,Yangbo LI,Jixuan LIU,Lingling SUN. Miniaturized lensless microfluidic on-chip bio-imaging detection[J]. Chinese Journal on Internet of Things, 2019, 3(2): 9-19.

Figures/Tables 13

References 70

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系统	阴影	全息	荧光
光源	单色光或白光	相干或部分相干	特定波长
结构特征	样本靠近像素平面	LED+小孔	滤光片
样本属性	不透光或部分透光	不透光或部分透光	荧光标记
计算量	中等	极大	中等
恢复彩色细节	可以	可以	不能

Miniaturized lensless microfluidic on-chip bio-imaging detection

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