Chinese Journal of Intelligent Science and Technology ›› 2020, Vol. 2 ›› Issue (2): 116-125.doi: 10.11959/j.issn.2096-6652.202013

• Surveys and Prospectives • Previous Articles     Next Articles

Brain abnormalities in depression based on multimodal imaging

Shan LI1,Yongchao LI1,Ying ZOU1,Lin YANG1,Yin WANG1,Zhijun YAO1,Ubin H1,2,3,4()   

  1. 1 Gansu Provincial Key Laboratory of Wearable Computing,School of Information Science and Engineering,Lanzhou University,Lanzhou 730000,China
    2 CAS Center for Excellence in Brain Science and Intelligence Technology,Shanghai 200031,China
    3 Joint Research Center for Cognitive Neurosensor Technology of Lanzhou University &Institute of Semiconductors,Chinese Academy of Sciences,Lanzhou 730000,China
    4 Engineering Research Center of Open Source Software and Real-Time Systems (Lanzhou University),Ministry of Education,Lanzhou 730000,China
  • Revised:2020-05-06 Online:2020-06-20 Published:2020-07-14
  • Supported by:
    The National Key Research and Development Program of China(2019YFA0706200);The National Natural Science Foundation of China(61632014);The National Natural Science Foundation of China(61627808);The National Natural Science Foundation of China(61210010);The National Basic Research Program of China (973 Program)(2014CB744600);The Program of Beijing Municipal Science & Technology Commission(Z171100000117005)


In recent years,structural magnetic resonance imaging (sMRI) and functional magnetic resonance imaging (fMRI) are widely used in depression research.From the perspectives of morphology,structural network and functional network,the brain abnormalities of depression were explored to understand the pathogenesis,and to assist doctors in clinical diagnosis,treatment and prognosis.A large number of researches have found that the hippocampus and amygdala of depression showed different degrees of atrophy,and the connection strength of brain network and graph theory attributes showed significant abnormal.Moreover,the abnormal brain areas were related to emotional regulation,attention and cognitive control,and the degree of abnormalities were highly correlated with the severity of depression.The research actuality of depression from different perspectives was reviewed,and some suggestions for future research were put forward.

Key words: depression, brain network, multimodality, magnetic resonance imaging

CLC Number: 

No Suggested Reading articles found!